Human papillomavirus type 16 does not require cathepsin L or B for infection
نویسندگان
چکیده
منابع مشابه
Heparan Sulfate of Human Keratinocytes Does Not Require Human Papillomavirus Type 31b Infection
متن کامل
Human papillomavirus type 31b infection of human keratinocytes does not require heparan sulfate.
Oncogenic human papillomaviruses (HPVs) are difficult to study experimentally as they replicate at low levels in vivo. This has precluded the purification of high-risk HPV virions from in vivo lesions. Virus-like particles (VLPs) and pseudovirions from low- and high-risk HPV types can emulate various aspects of HPV virion attachment and infections. These studies suggest that HPV infection is me...
متن کاملTarget Cell Cyclophilins Facilitate Human Papillomavirus Type 16 Infection
Following attachment to primary receptor heparan sulfate proteoglycans (HSPG), human papillomavirus type 16 (HPV16) particles undergo conformational changes affecting the major and minor capsid proteins, L1 and L2, respectively. This results in exposure of the L2 N-terminus, transfer to uptake receptors, and infectious internalization. Here, we report that target cell cyclophilins, peptidyl-pro...
متن کاملCathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.
Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained, approximately 4% encoded cathepsin K, a novel cysteine protease homologous to cathepsins S and L; ESTs for other cathepsins were rare. In addition, ESTs for cathepsin K were absent or at low frequency in cDNA libraries from numerous other tis...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2013
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.053694-0